semaglutide diabetes trial 2·4 mg once a week in adults with overweight or obesity, and type 2 (STEP 2): a randomised, double-blind, double-dummy, placebo-controlled, phase 3 semaglutide weight loss trial Long-term

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They appear to make them work better

Use your judgment: if the vial was stored perfectly, passes visual inspection, and is only slightly past BUD, many researchers make the informed decision to continue using it

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