Its been shown that altered glutathione concentrations may play an important role in many autoimmune pathological conditions prevalently elicited, determined and maintained by inflammatory/immune response mediated by oxidative stress reactions. Additionally, low levels of glutathione have been correlated with increased risk of leaky gut and imbalanced gut microbiomes
PubMed: 35975308Clinical (RCT / meta-analysis) ref-3.Lizzo G, Migliavacca E, Lamers D, Frezal A, Corthesy J, Vinyes-Pares G, Bosco N, Karagounis LG, Hovelmann U, Heise T, von Eynatten M, Gut P A Randomized Controlled Clinical Trial in Healthy Older Adults to Determine Efficacy of Glycine and N-Acetylcysteine Supplementation on Glutathione Redox Status and Oxidative Damage
& Escribese, M
Treatment requires specialist prescribing, regular monitoring for adverse effects including pancreatitis, and integration with lifestyle modifications