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Week 34 Measurable changes begin for many people: appetite becomes easier to control snacking decreases early weight loss appears for many daily hunger feels more predictable This is often when people say, I can tell this is doing something. Week 48: Visible Weight-Loss Zone As the dose increases, results may become more noticeable

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In the context of concurrent GLP-1 agonism which is hypothesised to counterbalance glucagon's hyperglycaemic effects net glucagon receptor stimulation may enhance fat metabolism without causing clinically significant hyperglycaemia