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However, native amylin presents significant challenges for therapeutic use, including rapid enzymatic degradation, tendency to form pathological amyloid fibrils, and poor bioavailability when administered exogenously

(2024) review documents broad pleiotropic effects in animal models

Disease-related expression of the IL6/STAT3/SOCS3 signalling pathway in ulcerative colitis and ulcerative colitis-related carcinogenesis

Those committee members who made the recommendations are practicing pharmacists, physicians and patient representatives whose hands-on, real-world experience and expertise complement the regulatory knowledge of FDA's career staff