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K., Chae, J

Consent for publication Written Informed consent for the clinical details was obtained by all participants prior to writing of the paper in accordance with the Baystate ethics principals

Peptides are generally challenging to deliver orally or sublingually because they are large molecules that do not easily cross mucous membranes and are susceptible to enzymatic degradation in the mouth and GI tract

This aligns closely with the approximately 15% average weight loss seen with injectable Wegovy in earlier phase 3 trials, although the studies were not head-to-head and involved different designs and populations