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There are also several proposed direct renal effects including 2 , 3 , 8 : 1) Reduced intraglomerular pressure by activating tubuloglomerular feedback (TGF) on the basis of acute proximal tubular natriuresis 9 - 12 leading to afferent arteriolar vasoconstriction, particularly in the setting of renal hyperfiltration 13 - 19
But many GLP-1 users do not need another program layer
Avoid administration during or immediately after intense exercise
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