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It has been extensively studied for its role in melanogenesis and various physiological processes
Although most patients experience grade 1-2 pneumonitis, it can rapidly escalate to a grade 3-4 irAE with a high mortality rate (50%-60%)
Unlike GnRH agonist, it does not trigger the initial surge of follicle-stimulating hormone and luteinizing hormone
Retatrutide is an investigational triple agonist targeting GLP-1, GIP, and glucagon receptors, currently under clinical investigation and not yet approved by the MHRA or EMA
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