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A 2020 review of case reports found that self-administered coffee enemas caused adverse effects such as: abdominal pain bloody stool rectal pain or burning proctocolitis, or inflammation of the rectal lining colitis, or inflammation of the colon The review also noted three deaths following coffee enema
Fisetin suppresses chondrocyte senescence and attenuates osteoarthritis progression by targeting sirtuin 6
10.1038/s41398-022-01819-y 60
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