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A 2023 position statement from the Endocrine Society on GLP-1 receptor agonist therapy notes that "dose escalation intervals shorter than 4 weeks are associated with higher rates of treatment discontinuation and should be avoided in routine clinical practice." [11] That statement aligns with what SUSTAIN-7 and post-market real-world analyses have shown
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Caspase-mediated death pathways show reduced activation[6][8]
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