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Molecules that have reached clinical development include inhibitors of the nonstructural (NS) 3/4A serine protease and inhibitors of HCV replication that belong to different categories: nucleoside/nucleotide analogue and non-nucleoside inhibitors of the HCV RNA-dependent RNA polymerase (RdRp), NS5A inhibitors and cyclophilin inhibitors [9]

Unequivocally, we do not see the same effects in humans as we do in rodents, says Elizabeth Pearce, MD, an endocrinologist and thyroid specialist at Boston Medical Center

When they are stopped, appetite signals may return

This results in enhanced eumelanin synthesis and increased skin pigmentation in research models