Contrave: Nausea, constipation, headache, insomnia Increased blood pressure and heart rate Other effects: anxiety, dizziness, dry mouth, tremors, risk of seizures in susceptible individuals Serious risks: liver problems, severe allergic reactions, neuropsychiatric events, including mood changes or suicidal thoughts Wegovy: Gastrointestinal issues: nausea, vomiting, diarrhea, constipation, abdominal pain Other effects: fatigue, headache, dizziness (especially during dose escalation) Serious risks: pancreatitis, gallbladder disease, thyroid tumors in high-risk patients, increased heart rate Important: Neither medication is a cure for obesity

Because persistent adipose tissue inflammation and fibrosis are major risk factors for post-weight loss metabolic deterioration, future studies should investigate whether prolonged Tir treatment or combination approaches targeting macrophage activation and fibrotic remodeling can achieve more complete adipose tissue restoration and durable metabolic recovery
Resistance to echinocandin-class antifungal drugs
Side Effect Profile: advantage goes to Oveporexton