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Remarkably, significant conformational changes of ECL1 upon receptor activation were observed relative to their inactive conformations: (i) in the inactive GCGR, ECL1 forms a -hairpin conformation and further compacts -sheet with the stalk region
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The thinking is that these defendants might opt to offer substantial settlement payouts to quickly resolve the litigation and mitigate any negative publicity that could arise during a trial
Sex-disaggregated data were not consistently available at the trial arm level and were therefore not included in the analysis
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