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Digestive Diseases 28 , 802811, doi: 10.1159/000324289 (2010)

The history of epileptic therapy: an account of how medication was developed (1st ed.)

This is highly relevant as PKA-RI aggregates undergo LLPS to form biomolecular condensates 65 which spatially restrict PKA activity, leading to signal compartmentalisation 25 , explaining why the direct presence of endosomal GLP-1R at ERMCSs is required to assemble this signalling hub, and uncovering a new modality of GLP-1R signal transduction which involves the local assembly of a biomolecular condensate containing not only signalling mediators such as SPHKAP/PKA, and also presumably adenylate cyclase, but also downstream targets for PKA phosphorylation such as the MICOS complex and other ERMCS components, some likely found amongst the active GLP-1R interactors identified in our interactome analysis

No tolerance development has been documented, suggesting ongoing benefits with consistent use