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In one widely cited study, Dihexa restored cognitive performance in a rat model of Alzheimers to near-normal levels outperforming donepezil (Aricept), a standard FDA-approved Alzheimers treatment

This puts anyone following a strict vegan or vegetarian diet at a very high risk for deficiency

The authors themselves described it as a small preliminary study.[15] A 2025 pilot report described intravenous administration to two healthy adults at doses up to 20 mg, with no measurable changes in cardiac, hepatic, renal or thyroid biomarkers and no reported adverse effects.[16] Two individuals cannot characterise uncommon reactions, immunogenicity, long-term toxicity, reproductive safety or oncological risk

Pinealon : Supports circadian rhythm regulation and cognitive health