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Furthermore, NAD levels in the brain are essential for maintaining central nervous system (CNS) vascular integrity, due to NAD maintaining an energy supply that plays crucial roles in cell survival, such as having a protective factor in cerebral ischemia, since its disorder leads to energy depletion (13, 52)

Semaglutide may also be considered for patients with type 2 diabetes who have not achieved their desired blood sugar control with lifestyle changes and other medications

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