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Medium-chain triglycerides (MCTs) consisting of decanoate (C10:0) can improve glucose tolerance and inhibit HFD-induced obesity in mice by stimulating GLP-1 secretion through GPR84 [148]

Daily ICV injections of OXM over 7 days led to food intake reduction and increased weight loss compared with saline treated controls ( Concurrent to the pre-clinical studies, the first human study of oxyntomodulin was carried out in a small double-blind placebo-controlled crossover study ( ad-libitum food intake was significantly reduced in participants receiving OXM compared to saline control and a cumulative caloric intake reduction was observed up to 12 hours later

Microneedles with two-stage glucose-sensitive controlled release for long-term insulin delivery

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