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In addition to these findings on atherosclerotic plaque formation, GLP-1R agonists prevented the increase in plasminogen activator inhibitor type-1 (PAI-1) and vascular cell adhesion molecule-1 (VCAM-1) gene expression in response to TNF- or hyperglycemia in HUVEC through PKA pathway [24],[70]
10.1177/1479164111436236 97 KarimA.LaurentA.MunsakaM.WannE.FleckP.MekkiQ
Tirzepatide (Mounjaro, Zepbound) isnt recommended during pregnancy because human safety data are inadequate and animal studies have shown potential fetal risks
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