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B)MICROVASCULAR COMPLICATIONS (Damage to small blood vessels) These complications are more insidious developing quietly over years before clinical symptoms emerge

Researchers think this may be partly because of the weight loss

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Some clinical experts and recent Phase 3 reporting have also noted that weight loss in some participants has been substantial enough to raise questions about how much weight loss may be too much, particularly when these medications are used outside tightly controlled medical settings and without provider supervision