B-Lokus (Lancashire Heeler) Hunde Affected dogs show signs of

Affected dogs show signs of uncoordinated movements

the breed standard allows only one coat length (long or short variant is unacceptable)

with further clinical signs evident in early life

even small doses can be fatal

B-Lokus (Lancashire Heeler) Hunde Affected dogs show signs ofGene TYRP1 (Tyrosinase related protein 1) is responsible for chocolate liver brown colour in dogs. This coat colour is inherited recessively. There are 4 different variants on B Locus in Lancashire Heeler: bc, bs, bd and be. Combination of any two recessive alleles will result in chocolate liver brown colour (for example two bc alleles or one bc and one bs allele). Because TYRP1 gene is related to eumelanin production, it only affects dogs which have